TORONTO — PwC says the initial public offering market in Canada totalled $2.2 billion last year, less than half of what was seen in 2017.The firm says in all of 2018 there were 54 new equity issues on four exchanges that generated a total of $2.2 billion.That compared with the $5.1 billion raised from 37 IPOs in all of 2017.The largest IPO of 2018 was the $462-million Ceridian HCM Holding issue of the second quarter.It was followed by MAV Beauty Brands with $241 million and AltaGas at $239 million.Dean Braunsteiner, national IPO leader at PwC Canada, says while cannabis firms grabbed the headlines, a surge of activity on the Canadian Securities Exchange and a return of junior miners to the markets were also notable developments of 2018. The Canadian Press
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Patients in Cyprus suffering from rare diseases are dying because they cannot access free medicine, representatives of patient groups said on Monday.Speaking during a press conference to mark Rare Diseases Day, reps explained how several of the vital drugs prescribed to patients are either not available or, even they are, are so costly that people often travel to the north where drugs are cheaper to buy them.This applies for instance to patients suffering from Myasthenia Gravis, a disease characterised by muscle weakness, said the representative for a patients’ support group, Anna Zanettou.She said that in late 2014, one drug that sufferers depended on was removed from state hospital pharmacies. The reason given was that the drug was ‘off label’ which means the drug was not listed as being specifically for Myasthenia Gravis patients.Zanettou, however, insists the real reason was the cost as the drug had previously been available for treating the disease at state pharmacies for years.She added that even the alternative drug provided is off label too, and it is not even medically acceptable to 10 of the 30 patients who used it which means they need the original drug.“This costs €333 from private pharmacies for 20 days thus a patient needs €666 every month. It’s difficult to find the money because when a Gravis patient is also retired – because we retire early – how can we find this money?” she said.“Other patients are forced – and I’m sorry to say – to go to the occupied areas and purchase the same drug with the same ingredients for €180. It’s shameful.”Last month alone, three patients died, she said, adding that some sufferers have been forced to borrow money from loan sharks to get their hands on enough cash to purchase the necessary drugs.Rare diseases found in Cyprus include congenital heart defects, genetic neurological diseases, myopathies, metabolic syndromes, skeletal malformations, and rare diseases in the thalassaemia sector. At least 60,000 people in Cyprus suffer from some type of rare disease.Government approval for drugs was a long ordeal and they were often not approved, said head of the association of affected persons and friends, Marios Kouloumas.“This problem has existed for years,” he said.Zanettou described how one patient’s doctors had requested a drug from the pharmaceutical services.“They have not received an answer yet. Our patient has passed away and the doctor still hasn’t got a response.”Health Minister George Pamborides, who attended the press conference and is set to meet with Kouloumas’ association on Thursday, said he could make no excuses in response.“Solutions need to be found and they will, I reassure you,” he said.He explained that Cyprus was such a small market and therefore of little interest to large producers. This meant the state had little bargaining power with the pharmaceutical industry which could charge huge sums of money for patented products.“Soon we will take the initiative to attract other small EU member states and attempt to create a single body which will give us the coveted bargaining power so we can stand up to the big guys and get better prices,” he said.Referring to the National Health Scheme, Pamborides said it would undoubtedly protect patients from “catastrophic health spending”.Zanettou warned of ‘dynamic measures’ if problems were not solved, pointing out there was a case at the Supreme Court of a patient who was seeking to obtain their drug via a court order.Kouloumas expressed his hope that reports saying €6.4 million would be approved from the finance ministry for therapies necessary for some of their patients were true.The Myasthenia Gravis Association Cyprus is organising a free informative conference on March 5 at the Institute of Neurology at 10am.You May LikeInsured Nation – Auto Insurance QuotesNew Rule in Rowland Heights, California Leaves Drivers FumingInsured Nation – Auto Insurance QuotesUndoPopularEverythingColorado Mom Adopted Two Children, Months Later She Learned Who They Really ArePopularEverythingUndoIcePopMan Notices A Strange Hole In This Lake, So He Gets A Drone, Flies It Inside And Captures ThisIcePopUndo Concern over falling tourism numbersUndoTurkish Cypriot actions in Varosha ‘a clear violation’ of UN resolutions, Nicosia saysUndoPensioner dies after crash on Paphos-Polis roadUndoby Taboolaby Taboola
Compassion shapes our behaviour towards a person wronged and a wrongdoer and may lead us to help the wronged than to punish the wrongdoer, researchers have found.According to researchers from the University of Wisconsin-Madison in the US, a new set of studies suggests that compassion — and intentionally cultivating it through training —impacts the extent to which people punish the transgressor.“Any action — helping or punishing — can arise from compassion, which involves at least two components: a ‘feeling’ component of empathic concern and caring for the suffering of another; and a cognitive, motivational component of wanting to alleviate that suffering,” said lead researcher Helen Weng. Also Read – ‘Playing Jojo was emotionally exhausting’Published in the journal PLoS ONE, the findings said understanding what motivates people to be altruistic can not only inform our own behaviours, it may also play a role in creating more just societal institutions, including the legal and penal systems.These findings are built upon previous work by Weng and others, which demonstrates that as little as two weeks of compassion training can result in measurable changes in the brain.These previous studies measured altruistic behaviour in research subjects but did not separate helping and punishing behaviour to learn which is most related to compassion. Also Read – Leslie doing new comedy special with NetflixTo answer this question, the investigators tested whether compassion was related to helping or punishment in two studies where participants played the “Helping Game” or “Punishment Game”, using real money they could keep at the end of the game.In both games, participants watched through online interactions as one player with more funds chose to split an unfair amount of money with another player with no funds.In the Helping Game, the third-party observers could choose to do nothing or give some of their own funds to “help” the victim.In the Punishment Game, the third-party observers could choose to do nothing or “punish” the transgressor by spending their own funds to take money away from the wrongdoer.“People with higher empathic concern were more likely to help the victim than punish the transgressor. “But, interestingly, within the group of people who decided to punish the transgressor, those with more empathic concern decided to punish less,” Weng noted after the studies.