Early results suggest 1 dose of H1N1 vaccine may be protective

first_imgSep 10, 2009 (CIDRAP News) – Preliminary clinical trial results suggest that pandemic H1N1 vaccines made by Novartis and CSL Ltd. will provide protection in adults with just one dose, raising hope for a less difficult immunization program than has been anticipated.Preliminary results for the two vaccines were published online this afternoon by the New England Journal of Medicine. The US Department of Health and Human Services (HHS) has ordered supplies of both vaccines, along with doses from three other companies.Federal officials have said they expected that a two-dose regimen of the H1N1 vaccines would probably be necessary to generate an adequate immune response to the novel virus. The first doses are expected to become available in mid October.In an editorial accompanying the vaccine reports, infectious disease expert Kathleen M. Neuzil, MD, MPH, called the findings welcome and reassuring.She noted that a one-dose schedule doubles the number of people who can be protected with a given amount of vaccine, and it also means that vaccinees are protected sooner, since a two-dose regimen typically involves doses spaced 3 weeks or more apart.”On the basis of these data, it would be appropriate to begin vaccination with the use of one dose of the usual antigen content,” Neuzil wrote. “In children, two doses may be needed, but vaccine should not be held in reserve to be used for a second dose.”British researchers tested the Novartis vaccine in a complex trial involving various doses formulated with or without the company’s proprietary adjuvant, MF59. The report is an interim analysis of responses to 7.5 micrograms (mcg) of adjuvanted vaccine after 14 and 21 days in 100 volunteers. The volunteers were between the ages of 18 and 50.By 21 days after vaccination with one 7.5-mcg dose of adjuvanted vaccine, 76% and 92% of volunteers showed a potentially protective immune response as measured, respectively, by hemagglutination inhibition and microneutralization assays, according to the report.Some of the volunteers received a second 7.5-mcg dose 7 or 14 days after the first. By day 21, those subjects had immune-response rates ranging from 88% to 92% and 92% to 96%, as measured by the two different methods.”Although two doses (for a total of 15 mcg of [hemagglutinin]) yield higher antibody levels than one dose, the seroprotective titer was attained in at least 80% of subjects in every group,” Neuzil wrote in commenting on the Novartis study.However, she added that with no data yet on the response in those who received non-adjuvanted doses, it’s not possible to assess the contribution of the adjuvant. HHS has ordered supplies of two adjuvants, but no adjuvanted flu vaccine has ever been used in the United States.As for safety, 70% of the Novartis trial volunteers reported pain at the injection site and 42% had muscle aches, the report says. Two of the vaccinees had a fever after the first dose.The CSL trial, conducted by company researchers in Australia, involved 240 adults, divided into two groups by age: under 50 and 50 and older. In each group, volunteers received either 15 mcg or 30 mcg of antigen.By 21 days after vaccination, an immune response (an antibody titer of 1:40 or more) was observed in 116 of 120 volunteers (97%) who received 15 mcg and in 112 of 120 (93%) who received 30 mcg.The report says 46% of the volunteers reported injection-site tenderness or pain, while 45% had systemic symptoms such as headache. Nearly all the problems were described as mild to moderate, and there were no serious adverse events.”These results are welcome and reassuring, as there is little evidence of cross-reactive antibody against the novel 2009 pandemic influenza A (H1N1) virus in the general population, and the need for two doses had been predicted,” Neuzil commented in her editorial.But without a non-vaccinated control group, it’s not possible to know whether any of the volunteers had a subclinical H1N1 infection that boosted their response to the vaccine, she added. The virus was circulating in Australia as the trial was being conducted, she noted.She also noted that children’s responses to the H1N1 vaccines remain to be seen.On the safety side, Neuzil said both vaccines have “generally acceptable” side-effect and adverse-event profiles, though the local reactions to the adjuvanted vaccine were somewhat higher than those generally seen with nonadjuvanted doses. The trials were not large enough to reveal rare adverse events, she added.HHS officials have ordered a total of 195 million doses of H1N1 vaccine from five manufacturers. Federal officials have said that Novartis will contribute about 45% of that supply and CSL about 19%.Other companies with H1N1 vaccine orders from HHS are Sanofi Pasteur, GlaxoSmithKline, and MedImmune.Greenberg ME, Lai MH, Hartel GF, et al. Response after one dose of a monovalent influenza A (H1N1) 2009 vaccine–preliminary report. N Engl J Med 2009 (published online Sep 10) [Full text]Clark TW, Pareek M, Hoschler K, et al. Trial of influenza A (H1N1) 2009 monovalent MF59-adjuvanted vaccine–preliminary report. N Engl J Med 2009 (published online Sep 10) [Full text]Neuzil KM. Pandemic influenza vaccine policy–considering the early evidence. (Editorial) N Engl J Med 2009 (published online Sep 10) [Full text]last_img read more


A new authentic ethno Turopolje gastro fairy tale near Zagreb

first_imgThe journey of tastes is equal to the greatest pleasures that make our wishes come true, it awakens our senses and provides an unforgettable feeling, and it is through this hypothesis that a new gastronomic fairy tale was created – Ethno Park Zagreb.The ethno park represents a journey through Turopolje through a unique story, and the current cultural offer of this interesting picnic area is richer for a new chapter that permeates from historical influences to the present day. The traditional cuisine of continental Croatia, including Turopolje, was under various influences, from Hungarian and Central European, all the way to Turkish and Arabic cuisine from the east. Ethno Park Zagreb with its rich historical collection provides an insight into a large part of these historical events. ” Within the Ethno Park Zagreb, there is a smaller wooden house, but nothing more modestly decorated. Then the summer house, where you will find refreshment during the hot summer days, and on slightly colder days, the same place will turn into a magical winter garden, where you will be warmed by a cup of tea or mulled wine. Right next to the summer house there is a charming children’s playground where games, laughter and new friendships are not lacking. Then we come to an elegant hall that is intended for celebrations and gatherings, and is arranged and adjusted according to your wishes depending on the type of occasion. ” stand out from the Ethno Park Zagreb.Special attention is paid to the preparation of meals, so that the ingredients of local farms prevail, and the delicacies are unique in the way the Ethno Park is prepared, which includes the recipes of our grandmothers. A special focus is on authentic dishes such as cooked štruklji in Turopolje, baked homemade fuži with fresh cheese as well as old Turopolje soups. In addition to those historical recipes, Erno Park pays attention to new combinations of dishes such as veal medallions in apple and honey sauce, but also old desserts such as grandma’s pancakes with grated apples and caramel topping. ”At the very end, although at first it seems as if there is no end, because we are located on an area of ​​40 000m2, a special place is occupied by an orchard, which is adorned with about 800 trees of various fruits. What will especially impress you during a walk through the orchard, especially in the evening, is the view that reaches straight to Sljeme, the highest peak of our Zagrebačka gora Medvednica.”The magical Ethno Park is located just a few kilometers from the center of Zagreb in Mala Mlaka and an irresistible, magical and peaceful place is an escape into some past times, a visit to the rich history of Croatian regions, and most importantly tells our authentic story.last_img read more


Zadar hotel is a golden label of HolidayCheck quality

first_imgPortal HolidayCheck, jedan od vodećih svjetskih portala za rezervacije i recenzije putovanja i smještaja, mjesečno posjeti 20 do 30 milijuna jedinstvenih korisnika koji napišu oko 10 milijuna komentara i recenzija o odredištima i smještaju. Te upravo prema ocjenama i recenzijama gostiju, koje je najvrednije i najbolji dokaz kvalitete, dodijeljena je Holiday Check Gold Award 2018 nagrade.Popis nagrađenih hotela objavljen je ovih dana na tom portalu, a među mnogobrojnim hotelima iz Hrvatske zadarski . Falkensteiner Club Funimation Borik prvi je i jedini koji je nagrađen “zlatnim odličjem”. A koliko je ovo priznanje značajno dovoljno govori činjenica kako je za ovu titulu potrebno najmanje 5 godina zaredom osvojiti nagradu Holiday Check Award što je zadarski hotel postigao od 2013. – 2018. godine.”U Falkensteineru se godinama kontinuirano ulažu značajna sredstva u obnovu hotela i repozicioniranje na tržištu. Hotel Club Funimation u ovom trenutku prolazi kroz rekonstrukciju i proširenje usluge kako bi ponovno bio spreman odgovoriti na sve izazove. U 2018. godinu krećemo s novim, poboljšanim proizvodom te se moramo maksimalno fokusirati na pronalazak kvalitetnog osoblja, kvalitetnu operativnu pripremu i na optimalno otvorenje hotela”, kažu iz Falkensteinera.Od ostalih hotela iz Hrvatske HolidayCheck nagradu za izvrsnost osvojili su: Hotel Miramar (Opatija), Aminess Maestral Hotel (Novigrad), Falkensteiner Hotel & Spa Iadera (Zadar), Bretanide Sport & Wellness Resort (Bol), SENTIDO Kaktus Hotel (Supetar). Za ovogodišnje nagrade za najpopularnije hotele u svijetu HolidayCheck je u obzir uzeo mišljenja i recenzije više od 980 tisuća hotelskih gostiju.Side dish. Holiday Check Gold Award 2018last_img read more


The competition for the selection and appointment of the director of the Tourist Board of the City of Stari Grad has been announced

first_imgA competition has been announced for the selection and appointment of the director of the Tourist Board of the City of Stari Grad.Tourist stories, potentials, resources,…. and challenge as much as we want. The island of Hvar is a UNESCO island. The historical core of the Old Town and the cultural landscape of the Old Town Field were inscribed on the UNESCO World Heritage List in 2008, and there is also the Procession of the Cross, Agave lace, klapa singing and Mediterranean food. And this is just the beginning of the whole tourist story that the whole island of Hvar has.Hvar and the Old Town need a visionary and proactive person, who has practical experience, and the rest is just a form that is less important. However, the conditions of the tender are attached, and the deadline for submission is 15 days from the date of publication (published on November 09.11.2018, XNUMX). Good luck everyone.Priog: Competition for the selection and appointment of the director of the Tourist Board of the City of Stari GradRELATED NEWS:THE OLD TOWN ON HVAR HAS DECIDED TO BAN THE OPENING OF NEW HOSTELSlast_img read more


Research shows that trust is the most important factor for Croatian customers when shopping online

first_imgBut since we know that it is 10 times cheaper to return an existing customer than to get a new one, they were also asked what is most important to them to repeat the purchase. As expected, most of them will return if they aresatisfied with the purchase and service, and only after that if they are satisfied with the purchased product, and if the trader pointed them out attractive new offers. Therefore, good user experience with a retailer is most important to most online shoppers, which suggests that the most important factor on the internet – gain the trust of customers. The eCommerce Croatia Association conducted a survey of 1959 online customers with the help of its members – web retailers. More than 36 percent of respondents shop online at least once a month, while as many as 20 percent shop several times a week. The surveyed Croats mostly buy clothes and shoes on the Internet, followed by household items and electronic devices. Also, a significant portion of them buy online travels and tickets. According to information obtained from merchants who participated in the survey, 50 to 70 percent of purchases end with the choice of payment upon collection, but when these same customers are asked which payment method they prefer, most of them like the “card”, while “cash on delivery” second, and PayPal in a high third. The aim of the research was to find out what online shoppers in Croatia want, what they buy most often, which payment methods they prefer, how they make the purchase decision, and what bothers them the most after the purchase. Although as many as 23,4 percent of respondents give up shopping due to the search for a better price, slightly more of them give up due to negative reviews. When asked about the most important criteria for the first purchase, they put “the possibility of preferred payment”, But follow in their footsteps”positive customer reviews”And”safe purchase certificate”. One of the reasons for the discrepancy between desire and reality is probably the “fear of data theft” that still has over 56 percent of respondents, but also the fact that they can not ask for a card and type data. Given the recent introduction of a new PSD2 regulation that brings biometric verification, it is believed that the card payment process will be facilitated in the future. Source / photo: Ecommerce Croatia Although the research did not directly address the tourism sector, it provides a good overview and reveals the habits of online consumers. As we can see, if customers are satisfied with the quality of service, they are willing to repeat the purchase. On the other hand, if the reviews are negative, the buyer will cancel the purchase. Also, it is interesting that the possibility of preferred payment to customers is even more important than negative reviews, so every caterer and renter should offer several different payment methods when booking a tourist offer. According to the data of the Ecommerce Foundation from the Netherlands, Croatian ecommerce is continuously growing from year to year, and in 2019 it reached 449 million euros, which is about 6 percent of the total value of retail in the Republic of Croatia. Over 70 percent of the population in Croatia uses the Internet, and almost half of Croats have bought something online at least once. But how many of them do it a little more often?last_img read more


Renters, how do you greet your guests?

first_imgYou can access the survey HERE The survey is anonymous, meaning that the data will only be used in aggregate form for statistical processing and individual responses will not be analyzed. Photo: Pixabay.com If you are engaged in renting in tourism, take 5 minutes and fill out a short survey that will help explore how to greet guests in private accommodation. The purpose of the research is to improve the experience of guests by developing new services to provide support to renters, which is carried out by dr.sc. Klara Trošt Lesić.last_img


Starting tomorrow, Holiday Week worth starting: 400 tourist services and experiences available at 50 percent lower prices

first_img“I am glad that we have decided to launch this completely new project just in time of crisis, in the days when we all need to get away from the news and enjoy nature with our loved ones. I hope that this Week will arouse in all of us optimism and the will to get to know the whole of Croatia better, and that we will truly enjoy the charms of the off-season in a large number of destinations, with many benefits. With projects like this, we open the way and promote the offers and services of tourist entities, but also small entrepreneurs, family farms, farmers, caterers, craftsmen and all other valuable people who are the foundation of the success of Croatian tourism. Thanks to the excellent response of providers, but also of all tourists who have already confirmed their reservations, I am sure that this week will be the first of many. Make this week worth your vacation”, said the Minister of Tourism and Sports Nikolina Brnjac. Thus, all Croatian citizens, but also foreign guests who will be in Croatia in that period, at promotional prices can experience and experience about 400 various tourist services in all parts of Croatia that are available on the portal “A week of rest worthwhile”. Numerous national parks and nature parks are participating in the project, including the Mljet National Park, which is celebrating its 60th anniversary, on the occasion of which they are offering half the ticket prices, and the Plitvice Lakes National Park. whose is director Tomislav Kovačević stressed that this year the park marks the 71st anniversary of the proclamation of Plitvice Lakes as a National Park and the 41st anniversary of the inscription of the park on the UNESCO World Heritage List. “In order to celebrate our 41st birthday with our visitors, we are participating in the Holiday Week worthwhile project with significantly better ticket prices and cheaper menus at the Jezero, Poljana and Korana restaurants. Proud to be a part of this story, we invite everyone to visit us and see why millions of tourists from all over the world have been heading to Plitvice Lakes National Park in recent years.”, said Kovacevic.  BRAVO LIKA. GREAT EXAMPLE OF HOW TO TELL A STORY FOR THE “HOLIDAY WEEK WORTH IT” LOUD THINKINGS / / / WEEKLY HOLIDAYS WORTH IT Otherwise, the action will be organized twice a year, during the Easter holidays and in October. HOLIDAY WEEK VALID: 340 BIDS HAVE BEEN APPLIED TO THE PROJECT SO FAR. GET INVOLVED, BUT NOT ONLY WITH A DISCOUNT, BUT PRIMARILY WITH A STORY “We note the excellent response of many tourism service providers involved in this action, without which a worthwhile holiday week would not be possible, and we are pleased to hear that many tourism entities have already sold out their offers and services. I invite as many domestic guests as possible to take this opportunity and discover Lijepa naša at much better prices, of course adhering to all prescribed epidemiological measures. We are pleased that despite the demanding moment we have launched this project which will continue in the coming years” pointed out the director of the Croatian Tourist Board Kristjan Staničić. Tourist services and experiences within the joint project of the Ministry of Tourism and Sports and the Croatian National Tourist Board “A week of rest worthwhile”, from tomorrow until October 25, are available at a minimum of 50 percent cheaper.  HOW TO USE THE “HOLIDAY WEEK WORTH” ACTION, AND IT HAS AN EFFECT FOR EVERYONE. THE KEY WORD IS SYNERGY As we know, the goal of the project A week of vacation worth it is the increase in tourist traffic in the pre- and post-season periods, as well as the further development of domestic tourism. Through this action, tourists will have the opportunity to visit different parts of Croatia with 50 percent better prices for many tourist products and services, from accommodation, transportation, cultural, historical, natural sights and tourist attractions to catering services and various experiences.last_img read more


Resolve to give more to others this year

first_imgCategories: Letters to the Editor, OpinionEvery year, thousands of people set out to make a New Year’s resolution. Here is a different thought and a different direction we should all try. Instead of giving up chocolate, fatty foods or maybe something as little as how much television we watch, let’s try a different approach. Let’s just give. We can get caught up in our busy schedules and at times lose our focus on what is really important. Let us take the time to think of all who are around us. Even if it’s something as simple as holding a door open, picking up something that someone has dropped, or just being polite by saying hello, there are all kinds acts that can make a difference in a person’s day. When we go home, let us think of our husbands, wives, children, parents or whoever else may be there. Instead of having our own favorite meal, maybe we could consider what others might like instead. Another nice gesture would be to clean up after dinner instead of having someone else do the task. I could list a hundred different ideas on what kind of thoughtful acts we could perform, but that’s up to the individual.The important thing is to think of others. Do no wait, because there’s going to be a time when our loved ones will not always be here. So during the new year, put others first and remember that it’s much better to give than to receive.Sean DefresneAmsterdamMore from The Daily Gazette:Foss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Find a way to get family members into nursing homesEDITORIAL: Beware of voter intimidationlast_img read more


Town needs affordable housing for seniors

first_imgRotterdam is a nice place to live. Its residents are mostly folks that are getting older or families. I’ve lived here all my life. All around, new apartments are going up — most of them for “seniors” or those “over 55.” That’s great, but most senior citizens can’t afford them. Although some can, let’s focus on the masses who can’t. We live on a very limited income and usually are alone. You really expect a senior to afford $1,200 and up for an apartment? Where do the food, prescriptions and other daily living necessities come in? We worked hard all our lives. Why can’t contractors find it in good conscience to think of the elderly? We are quiet, no parties, no police. We just want to be able to call someplace our home and live our lives there. How about building new apartments for the seniors in Rotterdam that are affordable? Really affordable. Most of us have had to sell our homes or give them up. This would be so wonderful for those that need a place to live.Karen EpliteRotterdam More from The Daily Gazette:Foss: Should main downtown branch of the Schenectady County Public Library reopen?EDITORIAL: Urgent: Today is the last day to complete the censusEDITORIAL: Beware of voter intimidationEDITORIAL: Find a way to get family members into nursing homesEDITORIAL: Thruway tax unfair to working motorists Categories: Letters to the Editor, Opinionlast_img read more


Catching the DIRFT

first_imgWould you like to read more?Register for free to finish this article.Sign up now for the following benefits:Four FREE articles of your choice per monthBreaking news, comment and analysis from industry experts as it happensChoose from our portfolio of email newsletters To access this article REGISTER NOWWould you like print copies, app and digital replica access too? SUBSCRIBE for as little as £5 per week.last_img