© molekuul_be/Shutterstock.comAs reported in the journal AIDS, Dr Ruth Ruprecht and colleagues have shown in an animal model that immunoglobulin M (IgM) prevented infection after mucosal AIDS virus exposure.Globally, around 90% of new cases of HIV-1 infection arise through exposure to the virus in mucosal cavities such as the lining of the vagina or rectum.Related StoriesPrevalence of anal cancer precursors is higher in women living with HIV than previously reportedEven when HIV prevention drug is covered, other costs block treatmentHIV therapy leaves unrepaired holes in the immune system’s wall of defense”IgM is sort of the forgotten antibody. Most scientists believed its protective effect was too short-lived to be leveraged as any kind of protective shield against an invading pathogen like HIV-1,” says Ruprecht.For the study, six Rhesus monkeys were treated with a synthetic version of IgM, an antibody produced by plasma cells under the surface epithelium of bodily cavities. Thirty minutes later, the animals were exposed to simian-human immunodeficiency virus (SHIV).Ruprecht and colleagues report that following this exposure, four of the six animals were fully protected against infection with the virus. They found that treating the monkeys with IgM resulted in what is referred to as immune exclusion – the antibody agglutinates the virus and stops it from passing through the epithelial barrier into the bloodstream where it could then spread to other parts of the body.Ruprecht says IgM has a high affinity for its antigens, grabbing them very quickly and not letting go: “Our study reveals for the first time the protective potential of mucosal anti-HIV-1 IgM. IgM has a five-times higher ability to bind to virus particles compared to the standard antibody form called IgG. It basically opens up a new area of research. IgM can do more than it has been given credit.”In an accompanying editorial, Ruprecht’s work has been referred to as setting off a new wave in evaluating the activity of IgM antibodies in neutralizing HIV-1: “[She and her group] have largely broadened the horizon of neutralizing HIV-1 antibodies, which, as single or combined agents, may be used for HIV-1 prevention and treatment.”The article describing the new and exciting findings has been listed as “Fast Track,” due to the special attention it should receive and generate. Source: https://eurekalert.org/pub_releases/2018-07/tbri-rsa072318.php By Sally Robertson, B.Sc.Jul 24 2018A team of scientists from Texas Biomedical Research Institute have homed in on an antibody that could protect against infection with HIV-1.
Loading …Follow us on Twitter. Do you favor or oppose allowing legal gun owners in Kansas to carry concealed weapons in public without a license or certification of formal training? I favor it. I’m opposed to it. View Results Close Forgot password? Please put in your email: Send me my password! Close message Login This blog post All blog posts Subscribe to this blog post’s comments through… RSS Feed Subscribe via email Subscribe Subscribe to this blog’s comments through… RSS Feed Subscribe via email Subscribe Follow the discussion Comments (14) Logging you in… Close Login to IntenseDebate Or create an account Username or Email: Password: Forgot login? Cancel Login Close WordPress.com Username or Email: Password: Lost your password? Cancel Login Dashboard | Edit profile | Logout Logged in as Admin Options Disable comments for this page Save Settings Sort by: Date Rating Last Activity Loading comments… You are about to flag this comment as being inappropriate. Please explain why you are flagging this comment in the text box below and submit your report. The blog admin will be notified. Thank you for your input. +15 Vote up Vote down anonymous · 276 weeks ago This is a no-brainer, common-sense law about to go into effect. It will deter a lot of crime. Ask cops in common-sense states…criminals think twice when they dont know who is packing. The state and a few entrepreneurs were just making money on permits and classes. All non-criminals have the right to bear arms and all who bear them have responsibility to practice gun safety. Report Reply 1 reply · active 276 weeks ago +5 Vote up Vote down Home Town Boy · 276 weeks ago AMEN anonymous, very well said. Several people have been enjoying raping people to give them their permits. There was no way they were going to flunk you not with $800 plus to get a permit. It was all a scam. Report Reply 0 replies · active 276 weeks ago +8 Vote up Vote down Ted Logan · 276 weeks ago Well regulated militia. Report Reply 1 reply · active 276 weeks ago +5 Vote up Vote down Joseph · 276 weeks ago Certificate for a concealed weapon is only to regulate handguns. Rifles and shotguns do not need to be certified. A couple hours of training does not do any good and is only red tape. Satistics on concealed weapons are the same in states with or without regulation. Report Reply 0 replies · active 276 weeks ago -6 Vote up Vote down Guest · 276 weeks ago Anonymous I agree you are a no brainer. The big issue is not the fact that people will be carrying concealed guns without proper training, it`s the fact that they will be carrying without going through the proper back ground checks, that is required to get a permit.__This new law would allow these so-called gang bangers and mentally people carry as long as they did not have a felony, just what we need???. And it does not cost $800 to get a permit more like $125 and you can renew it every 4 years for $25.00, If you can`t afford that, you can`t afford a gun…. Report Reply 2 replies · active 276 weeks ago +1 Vote up Vote down Blake · 276 weeks ago Can anyone who supports a conceal license have a reason for doing so? There isn’t any evidence supporting that it does any good. Report Reply 0 replies · active 276 weeks ago +10 Vote up Vote down blueskies · 276 weeks ago As a detective friend of mine once told me “a lot of bad attitude walks out of mini-marts when the knucklehead sees a 9mm on someone else’s hip.” Report Reply 0 replies · active 276 weeks ago 0 Vote up Vote down neil · 275 weeks ago It would definitely make it harder for one to purchase a gun if they didn’t meet the requirements. Further, if were to own a business where fire arms were sold would that not way on the conscience. Also, I am confused about how anyone would just go out and get a gun. I am not saying it doesn’t happen, but I imagine it might be a little tougher than that. Report Reply 1 reply · active 275 weeks ago 0 Vote up Vote down WHS73 · 275 weeks ago I have my permit & was opposed when I 1st heard about it. But the more I thought about it my opposition didn’t make sense. Having recently made my 1st handgun purchase, I can say that it is not easy even with a permit. I was told that it’s even more involved when you don’t have a permit. Permit holders don’t wear their permits for all to see so if you catch a glimpse of someone’s concealed weapon you have no way of knowing whether they have a permit or not. Bottom line is what it’s always been. Those who wouldn’t qualify for a permit would not qualify to legally purchase a handgun either. Yet these are the people who manage to obtain guns anyway if they want them. Laws only work when you’re dealing with law-abiding people. Take note though if you’re thinking about forgoing a permit. If you travel out of state for any reason a permit allows you to conceal-carry in reciprocating states. But with no permit you cannot. So be warned. Report Reply 0 replies · active 275 weeks ago Post a new comment Enter text right here! Comment as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. If you have a website, link to it here. Posting anonymously. Tweet this comment Submit Comment Subscribe to None Replies All new comments Comments by IntenseDebate Enter text right here! Reply as a Guest, or login: Login to IntenseDebate Login to WordPress.com Login to Twitter Go back Tweet this comment Connected as (Logout) Email (optional) Not displayed publicly. Name Email Website (optional) Displayed next to your comments. Not displayed publicly. 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