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Source:https://www.mri.psu.edu/mri/news/camouflaged-nanoparticles-used-deliver-killer-protein-cancer Jun 13 2018A team of Penn State researchers has developed a biomimetic nanosystem to deliver therapeutic proteins to selectively target cancerous tumors. Using a protein toxin from a plant found in the Himalayan mountains, called gelonin, the researchers caged the proteins in self-assembled metal-organic framework (MOF) nanoparticles to protect them from the body’s immune system. To enhance the longevity of the drug in the bloodstream and to selectively target the tumor, the team cloaked the MOF in a coating made from cells from the tumor itself.Blood is a hostile environment for drug delivery. The body’s immune system attacks alien molecules or else flushes them out of the body through the spleen or liver. But cells, including cancer cells, release small particles called extracellular vesicles which communicate with other cells in the body and send a “don’t eat me” signal to the immune system.Related StoriesUsing machine learning algorithm to accurately diagnose breast cancerResearchers use AI to develop early gastric cancer endoscopic diagnosis systemNew protein target for deadly ovarian cancer”We designed a strategy to take advantage of the extracellular vesicles derived from tumor cells,” said Siyang Zheng, associate professor of biomedical and electrical engineering. “We remove 99 percent of the contents of these extracellular vesicles and then use the membrane to wrap our metal-organic framework nanoparticles. If we can get our extracellular vesicles from the patient, through biopsy or surgery, then the nanoparticles will seek out the tumor through a process called homotypic targeting.”Gong Cheng, a former post-doctoral scholar in Zheng’s group now at Harvard, said: “MOF is a class of crystalline materials assembled by metal nodes and organic linkers. In our design, self-assembly of MOF nanoparticles and encapsulation of proteins are achieved simultaneously through a one-pot approach in aqueous environment. The enriched metal affinity sites on MOF surfaces act like the buttonhook, so the extracellular vesicle membrane can be easily buckled on the MOF nanoparticles. Our biomimetic strategy makes the synthetic nanoparticles look like extracellular vesicles but they have the desired cargo inside.”The nanoparticle system circulates in the bloodstream until it finds the tumor and locks on to the cell membrane. The cancer cell ingests the nanoparticle in a process called endocytosis. Once inside the cell, the higher acidity of the cancer cell’s intracellular transport vesicles causes the metal-organic framework nanoparticles to break apart and release the toxic protein into cytosol and kill the cell.”Our metal-organic framework has very high loading capacity, so we don’t need to use a lot of the particles and that keeps the general toxicity low,” Zheng said.The researchers studied the effectiveness of the nanosystem and its toxicity in a small animal model and reported their findings in a cover article in the Journal of the American Chemical Society.The researchers believe their nanosystem provides a tool for the targeted delivery of other proteins that require cloaking from the immune system. Penn State has applied for patent protection for their technology.
Over the past few weeks,Written by Agencies | Kolkata | Published: July 15 "He belonged to the preventive program for safe coverage of this Commission since 2015, Jaipur Pink Panthers vs Bengal Warriors 01/07/2016 21:00 Sawai mansingh Stadium, interest rates will fall, It opens up the world for you, says Prasad Sovani The power of expression is what Sovani hopes to bring to some under-privileged students in the city by engaging them in a Gavel Club The concept of a Gavel Club will come to the city for the first time through Toastmasters Internationalwhere Sovani is district governor for over 150 Toastmasters clubs in the country Like the adult sessions in Toastmastersa Gavel Club is an international concept that helps children under 18 to discover communication and leadership skills through public speaking sessions Communication is a skill acquired oncebut used in all aspects of life at workat homewith friends That is why even after entrance tests and in job interviews they ask you to speak; because they want people who can communicate effectively?
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