Individuals with herpes have reported seemingly unrelated symptoms such as constipation and urinary retention (inability to empty the bladder), but the mechanism was not understood. So the research team decided to investigate using mice models of herpes simplex virus-1, the dominant cause of genital herpes in the US.They found that the herpes virus spread from the genitals to nerves in the spinal chord, and then on to neurons in the colon, killing them. The damage to the colonic neurons prevented the movement of food along the digestive tract, leading to an enlarged colon and disease. Also Read – ‘Playing Jojo was emotionally exhausting’“The key findings is that there is this unexpected infection in the neurons in the colon wall after herpes infection,” said lead researcher Akiko Iwasaki, professor of immunobiology at Yale School of Medicine in New Haven, Connecticut, US. The findings were published in the journal Cell Host & Microbe.“Other members of the herpes virus family, including Epstein-Barr virus, chicken pox virus, and cytomegalovirus have been found in the neurons of the colon of people with unexplained chronic constipation,” Iwasaki, who is also an investigator at Maryland-based non-profit Howard Hughes Medical Institute, said.“When doctors can’t figure out the cause of these chronic intestinal conditions, one thing to look at is a viral infection,” she explained.
11 September 2008The Bond Exchange of South Africa (Besa) has secured the necessary approvals in support of its rights issue to raise new capital, with underwriting partners that include the New Zealand Exchange, local banks and other financial institutions securing the transaction.“We are tremendously excited by what the fresh capital injection and new partners will deliver for our business,” Besa chief executive Garth Greubel said in a statement last week.“The effect of this transaction is to significantly strengthen our shareholder and capital base, with certain strategic partners also being represented on the board, while maintaining our commitment to the bond market and existing shareholders.”The rights issue is the second phase of Besa’s development strategy, following the exchange’s demutualisation in 2007.After the rights issue, at least 30% of Besa’s equity will be held by strategic partners, providing valuable support in order to execute the exchange’s vision of building better markets. Formalities relating to the transaction will be concluded at Besa’s annual general meeting towards the end of September.BondClear projectAccording to Besa, a project that will contribute significantly in driving growth is BondClear, a new central counterparty clearing house that it is presently establishing. BondClear will provide clearing and central counterparty (CCP) services to South African financial markets, initially for interest-rate derivatives listed on the bond exchange.“We are optimistic about BondClear, in which NASDAQ OMX is a direct shareholder,” Greubel said. “NASDAQ OMX is one of the world’s largest exchange companies, with trading technology capabilities across six continents.”Shareholder and market support for the rights, the BondClear project and other strategic initiatives that Besa is undertaking have been positive, while company management has already received irrevocable commitments in writing from shareholders, in excess of the necessary requirements, approving the capitalisation transaction.Strong market performanceAccording to Besa, these initiatives are being undertaken against the backdrop of strong market performance in the exchange’s core bonds franchise.Annual bond market turnover topped R13.8-trillion in calendar 2007. During 2008 bond turnover surged, with a record monthly figure of R1.486-trillion reported in February.This has since been consistently exceeded from May through to August, when turnover reached a new record R1.956-trillion for the month. It is anticipated that turnover will top R17-trillion for 2008, representing an annualised velocity of 28 times market cap.Besa now faced one of the most exciting and ambitious phases in the company’s development as an exchange, Greubel said.“Our new capital will leave us well positioned to drive value through our existing core business and extend our set of products and services to financial market participants, as well as accelerating financial market infrastructure development in South Africa,” he said.“We are excited by what the future holds for us as a business and the positive contribution it will make towards strengthening competition in South African financial markets.”SAinfo reporter Would you like to use this article in your publicationor on your website?See: Using SAinfo material
YesNoI don’t knowVote Image: Shutterstock/Billion Photos Apr 6th 2017, 9:11 AM THE ISSUE OF third-level fees is one that rears its head every few months.Specifically, how to pay for them. Today on TheJournal.ie, Elizabeth Tandy Shermer argues that whatever Ireland does, we shouldn’t copy the American student loans scheme.But is some form of student loan the way forward?We’re asking: Should Ireland introduce third-level student loans for fees? 22,245 Views Poll Results: 69 Comments Share340 Tweet Email1 http://jrnl.ie/3326520 Image: Shutterstock/Billion Photos Poll: Should Ireland introduce third-level student loans for fees? Is some form of student loan the way forward? By Paul Hosford I don’t know (647) Yes (5170) Thursday 6 Apr 2017, 9:11 AM No (6820) Short URL Tweet thisShare on FacebookEmail this article
Las Vegas >> Bull rider Colby Demo, from Red Bluff, celebrated his birthday in style Thursday with a new Permit Challenge Champion buckle. Demo was the only cowboy to cover two bulls with 144.5 points total, according to a press release issued Friday by the Professional Rodeo Cowboys Association. He finished second in the first round, with a ride of 76.5 for $368. In the second round, he finished second with a ride of 68 for $497.With the win, Demo is eligible to purchase his rookie card to …